It comes after widespread disruption affected Euston on the Friday of the bank holiday weekend after thieves tried to steal signalling cables from the West Coast Main Line, triggering signal failures.
The problems affected passengers travelling with five separate train companies, including Avanti West Coast, CrossCountry, London Northwestern Railway, Transport for Wales and West Midlands Railway.
Services on the line, the busiest mixed freight and passenger railway route in western Europe, were already set to be reduced because of planned Network Rail engineering works around Crewe and Carlisle.
A £24 million upgrade project is under way to refurbish drains and carry out other maintenance works intended to make the trains more reliable in the future, and less susceptible to delays and cancellations caused by track faults and failures.
Network Rail has said it often carries out major engineering work over bank holiday periods to reduce the number of passengers impacted.
On the roads, Inrix, a transport analytics company, said it expected to see 3.4 million car journeys during bank holiday Monday as sunseekers returned home from the three-day weekend. The RAC said the worst time for congestion on Monday would be between 11am and 2pm.