The charity will be selling Christmas cards, advent calendars and gifts at Harpenden United Reformed Church on Vaughan Road from October 17.
The money raised will go towards national charities and the local community.
Over the last decade, Cards for Good Causes has raised more than £22.5 million for a network of over 100 charities, including NSPCC, RSPCA, WaterAid, Shelter, Carers UK, and The Ramblers.
In addition, they have contributed over £2.7 million to local churches, libraries, and community projects.
Christine Ansell, CEO of Cards for Good Causes, said: “In these times when every penny counts, we’re delighted to offer shoppers in Harpenden a unique opportunity to support charities that are changing lives while also strengthening local communities.
“Thanks to our committed partners, seasonal staff and local volunteers, we’re returning to the hearts of neighbourhoods across the country, providing a meaningful way for people to give this Christmas.”
The charity has been opening shops around the UK each year since 1959.
If you can’t make it to a pop-up shop, the full range is available online with same-day dispatch and free shipping on orders over £40.