Wyatt-Hodge’s departure from the Utilita Bowl was announced alongside that of team-mate Charlie Dean, who is also set to pursue opportunities outside Hampshire.
Off-spinning all-rounder Dean, 23, departs Hampshire having represented the county in various guises since under-13 level.
She became the fastest woman to take 50 one-day international wickets, reaching that milestone in just 26 matches, and has played for England in all three formats.
“I can’t speak highly enough of how important Hampshire and Southern Vipers have been in my cricketing journey,” Dean told the club website., external
“Since I joined Hampshire as a teenager, the coaches and staff have been exceptional, and it’s been a privilege to call Utilita Bowl my home since 2017.
“The successes we’ve had as a team have been nothing short of incredible, and I’ll look back fondly on my time here.”
Hampshire are among the eight counties selected to compete in Tier One of the sport’s new structure, along with Durham, Essex, Lancashire, Nottinghamshire, Somerset, Surrey and Warwickshire.