UPDATE 16:45: Latest advice from Avanti West Coast and TransPennine Express is to delay travel until 27th September.
Avanti West Coast says that no further rail replacement buses are available from Preston, Carlisle or Glasgow Central
Avanti West Coast is advising passengers not to travel north of Preston due to a tree falling on the overhead wires.
The incident has taken place between Motherwell and Lockerbie which means that all lines are blocked.
Major disruption is due to continue until end of service today (26th September).
Avanti West Coast has ticket acceptance in place with LNER (between London Kings Cross and Edinburgh), TransPennine Express, ScotRail (between Glasgow Central and Edinburgh), CrossCountry (between Birmingham New Street and Edinburgh) and Northern (between Newcastle and Carlisle).
TransPennine Express has ticket acceptance with CrossCountry (Glasgow/Edinburgh – Leeds and then change to TPE services to Manchester), LNER (Edinburgh – York) and ScotRail (Glasgow – Edinburgh).
TPE also says that when the line reopens, passengers can use Avanti West Coast services between Glasgow / Edinburgh and Preston and then change to a Northern service to complete journeys.
The latest travel advice can be found on the National Rail website.