Luton Airport said it carried more than 16.2 million passengers in 2023 and airlines already based there include easyJet, Wizz Air, Ryanair, Tui.
The airport’s chief executive Alberto Martin said it was “fantastic news” for passengers and “marks a major expansion of Jet2’s operations in the south of England”.
Mr Heapy said: “Customers and independent travel agents have been asking us to open at London Luton Airport for many years now.”
Jet2 already flies to 12 UK airports and has bases at 10 of them – but it does not already fly into Luton.
Ms Simmons said the news would bring “jobs and economic growth”
“Employment in and around the airport is already at record levels and today’s announcement will make another major contribution to the next chapter in its ongoing success.”