Europe’s other debutant Albane Valenzuela is out in the second match, alongside France’s Celine Boutier, who is the team’s highest-ranked player at 10 in the world.
“Let’s send them out and experience it,” said Pettersen of her decision to blood both her new players in the opening session.
“There’s no point for them to sit around and wonder what it’s going to be like.”
Lewis said it was “a bonus to get them both out there”, having also selected her two rookies in the opening matches.
Lauren Coughlin, who won last month’s Women’s Scottish Open, is making her debut at the age of 31 alongside former world number one amateur Rose Zhang, 21, against Valenzuela and Boutier.
Sarah Schmelzel, who is the lowest ranked US player at 58, will partner world number two Lilia Vu in the bottom match against Sweden’s Linn Grant and Spain’s Carlota Ciganda, who secured the point to ensure Europe retained the trophy last year in her homeland.
The other match features Sweden’s Maja Stark and Denmark’s Emily Pedersen against Ally Ewing and Jennifer Kupcho.
Among the players sitting out are Ireland’s Leona Maguire, who is missing a session for the first time after playing five matches in both her previous appearances.
“To sit Leona in a foursome is a tough call,” conceded Pettersen. “But you go a little bit with the gut. She has a great record and is a feisty Solheim player and you’ll see her.”
Lewis also defended her decision not to use Lexi Thompson and Megan Khang, who won both their foursomes matches last year. “I don’t think you’re going to see that pairing,” she added.
“We have a lot of good pairings and not everybody is going to play this session,” she added. “I don’t think I’ll have anybody play all five.”